Soluble CD40 ligand in acute coronary syndrome in cocaine users
Affiliation of the authors
Domínguez Rodríguez A, Abreu González P, Enjuanes Grau C, Juárez Prera R, Arroyo Ucar E, Burillo-Putze G. Soluble CD40 ligand in acute coronary syndrome in cocaine users. Emergencias. 2011;23:104-7
Background and objectives: The soluble CD40 ligand (sCD40L) expressed on platelets
is released in the activation process. We analyzed the sCD40L serum concentration in
cocaine users with acute coronary syndrome (ACS).
Patients and methods: Retrospective comparison of sCD40L serum concentration
between 40 patients with ACS and a positive test for cocaine in urine and 40 ACS
patients with a negative cocaine test.
Results: The mean (SD) sCD40L serum concentration in the patients with ACS and a
negative cocaine test was lower (110 [41.1] pg/mL) than in patients who were not
cocaine users (65.3 pg/mL) (P=.03). In the multivariable analysis, after adjustment for
age and coronary risk in these patients with ACS, a positive cocaine test remained
associated with sCD40L concentration.
Conclusions: The sCD40L plays a part in the proinflammatory thrombotic process in
cocaine users who develop ACS.