Summary

Soluble CD40 ligand in acute coronary syndrome in cocaine users

Domínguez Rodríguez A, Abreu González P, Enjuanes Grau C, Juárez Prera R, Arroyo Ucar E, Burillo-Putze G

Affiliation of the authors

Servicio de Cardiología. Hospital Universitario de Canarias. Tenerife, Spain. Departamento de Fisiología. Universidad de La Laguna. Tenerife, Spain. Servicio de Urgencias. Hospital Universitario de Canarias. Tenerife, Spain.

DOI

Quote

Domínguez Rodríguez A, Abreu González P, Enjuanes Grau C, Juárez Prera R, Arroyo Ucar E, Burillo-Putze G. Soluble CD40 ligand in acute coronary syndrome in cocaine users. Emergencias. 2011;23:104-7

Summary

Background and objectives: The soluble CD40 ligand (sCD40L) expressed on platelets

is released in the activation process. We analyzed the sCD40L serum concentration in

cocaine users with acute coronary syndrome (ACS).

Patients and methods: Retrospective comparison of sCD40L serum concentration

between 40 patients with ACS and a positive test for cocaine in urine and 40 ACS

patients with a negative cocaine test.

Results: The mean (SD) sCD40L serum concentration in the patients with ACS and a

negative cocaine test was lower (110 [41.1] pg/mL) than in patients who were not

cocaine users (65.3 pg/mL) (P=.03). In the multivariable analysis, after adjustment for

age and coronary risk in these patients with ACS, a positive cocaine test remained

associated with sCD40L concentration.

Conclusions: The sCD40L plays a part in the proinflammatory thrombotic process in

cocaine users who develop ACS.

 

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