Opportunistic screening for hepatitis C virus infection in an emergency department in Almeria, Spain
Anny Camelo-Castillo1, Teresa Jordán Madrid1, Teresa Cabezas Fernández1, Manuel Rodríguez-Maresca1, Antonio Duarte Carazo1, Alba Carrodeguas2, Diogo Medina2, Federico García3, Marta Casado-Martín1
Affiliation of the authors
1Hospital Universitario Torrecárdenas, Almería, Spain. 2Gilead Sciences, Spain. 3Plan para la Eliminación de la Hepatitis C en Andalucía; Hospital Universitario Clínico San Cecilio, Instituto de Investigación ibs. GRANADA; Ciber de Enfermedades Infecciosas, CIBERINFEC. Andalucía, Spain.
Camelo-Castillo A, Jordán Madrid T, Cabezas Fernández T, Rodríguez-Maresca M, Duarte Carazo A, Carrodeguas A, et al. Opportunistic screening for hepatitis C virus infection in an emergency department in Almeria, Spain. Emergencias. 2024;36:25-32
Summary
Background and objective.
The prevalence of active hepatitis C virus (HCV) infection in Spain is estimated to be 0.2%, but a large number of persons are unaware of their infection status. Additional approaches to early diagnosis of HCV infection in vulnerable populations with scarce contact with the national health care system are therefore needed. Our aim was to evaluate the impact of an opportunistic screening program to detect HCV-infected patients attended in our university hospital emergency department (ED).
Methods.
Opportunistic screening was implemented from August 2021 to April 2023 in ED patients aged 18 to 69 years. The test was ordered if HCV screening had not been done in the last year and blood extraction for testing was indicated for any reason as part of routine ED care.
Results.
A total of 110 267 patients were seen; 22 712 of them (20.6%) were eligible for screening. Serology for HCV was done for 11368 of the eligible patients (50.1%). Forty-three cases (in 0.4% of tested samples) of active HCV infection (viremia) were found. In 24 of these cases (56%) the patients had not been aware that they were infected. Their mean (SD) age was 57 (6) years, 34 (79.1%) were men, and 5 (11.6%) were citizens of countries other than Spain. No risk factors related to HCV infection could be found for 22 of the patients (51.2%), and 41 (95.3%) could have been diagnosed during previous contact with the health care system. Of the 18 patients evaluated by transient elastography (FibroScan), 7 (38.8%) had signs of cirrhosis at the time of diagnosis. Thirty-three of the patients with active infections (77%) were subsequently able to access care.
Conclusions.
The rate of active HCV infection in the screening program was higher than the prevalence estimated for the general population. Opportunistic screening for HCV during ED visits is useful for increasing the number of diagnoses and should be considered as a tool for eradicating this disease.
