Summary
Vernakalant in hospital emergency practice: safety and effectiveness
Carbajosa Dalmau J, Cosín-Sales J, Pérez-Durá MJ, Noceda J, Urtubia-Palacios A, Hernández-Sori N, Peiró-Gómez A, Jacob J, Llorens P, Ruescas-Gómez L, Martín-Martínez A
Affiliation of the authors
Servicio Urgencias,Hospital General de Alicante; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-Fundación FISABIO), Alicante, Spain. Grupo de Arritmias Cardiacas, SEMES. Servicio Cardiología, Hospital Arnau de Villanova, Valencia, Spain. Servicio Urgencias, Hospital Universitario y Politécnico La Fe, Valencia, Spain. Servicio Urgencias, Hospital de Sagunto, Valencia, Spain. Servicio Urgencias, Hospital de Elda, Alicante, Spain. Servicio Urgencias, Hospital Arnau de Villanova, Valencia, Spain. Servicio de Urgencias, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain. Servicio de Urgencias, Unidad de Corta Estancia y Hospitalización a Domicilio, Hospital General de Alicante; Departamento de Medicina Clínica, Universidad Miguel Hernández; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-Fundación FISABIO), Alicante, Spain. Servicio Urgencias, Hospital Universitario Severo Ochoa, Madrid, Spain.
DOI
Quote
Carbajosa Dalmau J, Cosín-Sales J, Pérez-Durá MJ, Noceda J, Urtubia-Palacios A, Hernández-Sori N, et al. Vernakalant in hospital emergency practice: safety and effectiveness. Emergencias. 2017;29:397-402
Summary
Objectives.
Methods.
Results.
common in patients who converted with vernakalant (6.3%) than in those who did not (18.9%) (adjusted odds ratio [OR], 0.45 [95% CI, 0.13–1.56]; P=.208). Having no prior history of AF was nonsignificantly related to greater effectiveness (in 54.7% vs in 35.1% with prior AF). Duration less than 12 hours was significantly associated with greater effectiveness (83.6% vs 59.5%; adjusted OR, 2.76 [95% CI, 1.12–6.80]; P=.028). Adverse events were reported for 30 patients. None of the events had clinically important consequences, and in only 2 cases (1.2%) was it necessary to suspend treatment.
Conclusion. Vernakalant is effective and safe for restoring sinus rhythm in the hospital emergency department.