Summary

Diagnostic groups and short-term outcomes in suspected COVID-19 cases treated in an emergency department

Martín-Sánchez FJ, González Del Castillo J, Valls Carbó A, López Picado A, Martínez-Valero C, Miranda JD, Chacón A, López-Ayala P, Chaparro D, Cozar López G, Suárez-Cadenas MM, Jerez Fernández P, Del Toro E, Cardassay E, Angós B, Díaz del Arco C, Rodríguez Adrada E, Montalvo Moraleda MT, Espejo Paeres C, Elvira C, García Briñón MA, Leal Pozuelo JM, Ortega L, Fernández Pérez C, González Armengol JJ


Affiliation of the authors

Servicio de Urgencias, Hospital Clínico San Carlos, Madrid, Spain. Facultad de Medicina. Universidad Complutense de Madrid, Spain. Instituto de Investigación Sanitaria del Hospital San Carlos, Madrid, Spain. Servicio de Neurología, Hospital Clínico San Carlos, Madrid, Spain. Repsol, Risk Division, Madrid, Spain. Servicio de Admisión y Documentación Clínica, Hospital Clínico San Carlos, Madrid, Spain. Cardiovascular Research Institute Basel (CRIB) and Department of Cardiology, University Hospital Basel, University of Basel, Basel, Suitzeland. Servicio de Anatomía Patológica, Hospital Clínico San Carlos, Madrid, Spain. Servicio de Cardiología, Hospital Clínico San Carlos, Madrid, Spain. Bioinformática, Hospital Clínico San Carlos, Madrid, Spain. Servicio de Medicina Preventiva, Hospital Clínico San Carlos, Madrid, Spain..

DOI

Quote

Martín-Sánchez FJ, González Del Castillo J, Valls Carbó A, López Picado A, Martínez-Valero C, Miranda JD, et al. Diagnostic groups and short-term outcomes in suspected COVID-19 cases treated in an emergency department. Emergencias. 2020;32:242-52

Summary

Objective.

The primary objective was to describe the clinical characteristics and 30-day mortality rates in emergency department patients with coronavirus disease 2019 (COVID-19) in different diagnostic groupings.

Methods.

Secondary analysis of the COVID-19 registry compiled by the emergency department of Hospital Clínico San Carlos in Madrid, Spain. We selected suspected COVID-19 cases treated in the emergency department between February 28 and March 31, 2020. The cases were grouped as follows: 1) suspected, no polymerase chain reaction

(PCR) test (S/no-PCR); 2) suspected, negative PCR (S/PCR–); 3) suspected, positive PCR (S/PCR+); 4) highly suspected, no PCR, or negative PCR (HS/no or PCR–); and 5) highly suspected, positive PCR (HS/PCR+). We collected clinical, radiologic, and microbiologic data related to the emergency visit. The main outcome was 30-day all-cause mortality.

Secondary outcomes were hospitalization and clinical severity of the episode.

Results.

A total of 1993 cases (90.9%) were included as follows: S/no-PCR, 17.2%; S/PCR–, 11.4%; S/PCR+, 22.1%; HS/no PCR or PCR–, 11.7%; and HS/PCR+, 37.6%. Short-term outcomes differed significantly in the different groups according to demographic characteristics; comorbidity and clinical, radiographic, analytical, and therapeutic variables.

Thirty-day mortality was 11.5% (56.5% in hospitalized cases and 19.6% in cases classified as severe). The 2 HS categories and the S/PCR+ category had a greater adjusted risk for 30-day mortality and for having a clinically severe episode during hospitalization in comparison with S/PCR– cases. Only the 2 HS categories showed greater risk for

hospitalization than the S/PCR– cases.

Conclusion. COVID-19 diagnostic groups differ according to clinical and laboratory characteristics, and the differences are associated with the 30-day prognosis.

 

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